Hello, I am Dr. Hidenori Shimada of Grand Green Osaka Umekita Clinic in Osaka, Japan.
Medical travel to Japan is becoming an increasingly popular option for individuals seeking advanced healthcare, including innovative treatments like regenerative medicine. Adipose-derived stem cell therapy, which utilizes your body’s own cells, is one such area of interest. However, undergoing a medical procedure in another country can naturally come with questions and uncertainties, especially regarding the process on the day of treatment. This guide provides a clear, step-by-step overview of what to expect on the day of your adipose stem cell therapy at Grand Green Osaka Umekita Clinic, designed to help international patients feel informed and at ease.
What to Expect: The Outpatient Procedure in a Nutshell
Adipose-derived stem cell therapy is a process that involves collecting a small amount of your own fat tissue, isolating and culturing the mesenchymal stem cells (MSCs) within it at a specialized facility, and then administering these cells back into your body, typically through an intravenous (IV) infusion. The procedures on the day of fat collection and the day of infusion are both performed on an outpatient basis, meaning no hospital stay is required. The typical flow involves a consultation, a minor procedure for fat collection under local anesthesia, and later, a separate appointment for the IV infusion. While this is a general outline, the specific details of your treatment plan will be determined by a physician based on your individual health condition. A thorough consultation with a doctor is essential before proceeding with any treatment.
Addressing Common Concerns for International Patients
When considering treatment abroad, it’s normal to have questions. Many of our international patients share similar concerns before their visit. We aim to address these points to ensure you feel comfortable and well-prepared.
- The Procedure Steps: What exactly happens from the moment I arrive at the clinic?
- Discomfort and Anesthesia: What is involved in the fat collection process? Is it a major surgery?
- Time Commitment: How long will I need to be at the clinic on the day of the procedure?
- Recovery: What are the immediate post-procedure guidelines and restrictions?
- Language and Communication: Will I be able to communicate effectively with the medical staff?
This article will walk you through the entire process, answering these questions to demystify your treatment day experience.
A Step-by-Step Guide to Your Treatment Day
The adipose stem cell therapy journey is divided into two main visits to the clinic: the day of fat collection and, after a few weeks of cell culturing, the day of IV infusion. Here’s a detailed look at what happens during each stage.
Visit 1: The Fat Collection Procedure
Step 1: Arrival and Final Consultation
Upon arriving at the clinic, you will have a final consultation with the physician. This is an opportunity to review your health status, confirm the details of the procedure, and ask any last-minute questions. You will also finalize the necessary consent forms.
Step 2: Fat Tissue Collection
This is a minor procedure performed under local anesthesia. The physician will make a very small incision, typically in the abdominal area, to collect a tiny amount of subcutaneous fat tissue—often just a few pieces the size of a grain of rice. Because only a small quantity is needed and local anesthesia is used, the physical burden is generally considered minimal. The collection process itself is usually completed in about 20-30 minutes.
Step 3: Post-Procedure Care and Departure
After the collection, the small incision is closed. You will be given instructions for at-home care. You can typically return to your daily activities shortly after, though strenuous exercise should be avoided for a period as advised by your doctor. This concludes your first visit.
The Interim Period: Cell Culturing
The collected fat tissue is sent to a specialized, licensed cell processing facility. There, mesenchymal stem cells are isolated, purified, and cultured over several weeks to multiply their numbers. This process is conducted under strict safety and quality controls as mandated by Japan’s Act on the Safety of Regenerative Medicine.
Visit 2: The IV Infusion Day
Step 4: Arrival and Preparation
A few weeks after the fat collection, you will return to the clinic for the administration of your cultured stem cells. After a brief check-up to ensure you are feeling well, you will be guided to a comfortable room for the infusion.
Step 5: IV Infusion
The cultured stem cells are administered back into your body through a standard intravenous (IV) drip. The process is similar to receiving any other IV treatment and typically takes about 30 to 60 minutes. During this time, you can relax comfortably.
Step 6: Post-Infusion Rest and Departure
Following the infusion, you will rest at the clinic for a short observation period. Once the medical staff confirms that you are well, you are free to leave. As with the collection day, this is an outpatient procedure, and you can return to your accommodation afterward.
Important Information Before Your Consultation
It is crucial for patients to have a clear understanding of the nature of this treatment. Adipose-derived stem cell therapy is provided as a private medical treatment and is not covered by Japanese public health insurance. The outcomes and responses can vary from person to person, and no results can be guaranteed. A physician’s consultation is necessary to determine if you are a suitable candidate for this therapy. During your consultation, the doctor will provide a detailed explanation of the expected benefits, as well as the potential risks and side effects. All treatments in Japan are provided under a plan submitted to and accepted by the Ministry of Health, Labour and Welfare, in compliance with the Act on the Safety of Regenerative Medicine.
Learn More About Stem Cell Therapy in Osaka
Understanding the process is the first step toward making an informed decision about your health. At Grand Green Osaka Umekita Clinic, located in the heart of Osaka, we are committed to providing clear information and support to our international patients. If you would like to explore adipose-derived stem cell therapy further, including its features, the science behind it, and the fee structure, we encourage you to review our comprehensive information page. It provides the details you need to prepare for a consultation with one of our physicians.
Discover more about Adipose-Derived Stem Cell Therapy here.Conclusion: A Clear Path for Your Treatment Journey
Embarking on a medical journey in a new country can feel daunting, but knowing what to expect can make a significant difference. The process for adipose-derived stem cell therapy is structured into clear, manageable steps, all conducted on an outpatient basis. From the initial fat collection to the final IV infusion, the focus is on patient comfort and safety. The most important step, however, is a thorough discussion with a qualified physician to understand if this treatment aligns with your personal health goals. We invite you to reach out to Grand Green Osaka Umekita Clinic to begin that conversation.
- 1Visit 1: Fat CollectionA minor procedure to collect a small amount of your fat tissue
- 2Interim: Cell CulturingYour stem cells are multiplied at a specialized facility for weeks
- 3Visit 2: IV InfusionAdministering the cultured cells back into your body via IV drip
This diagram provides a simplified overview of the process described in this article
References
- PubMed: Allogeneic mesenchymal stem cell therapy with laromestrocel in mild Alzheimer's disease: a randomized controlled phase 2a trial. (2025)
- PubMed: Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]). (2017)
- PubMed: Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial. (2025)
- PubMed: Safety and efficacy of umbilical cord tissue-derived mesenchymal stem cells in the treatment of patients with aging frailty: a phase I/II randomized, double-blind, placebo-controlled study. (2024)
- PubMed: Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicle Infusion for the Treatment of Respiratory Failure From COVID-19: A Randomized, Placebo-Controlled Dosing Clinical Trial. (2023)
- PMC: Optimal Intravenous Administration Procedure for Efficient Delivery of Canine Adipose-Derived Mesenchymal Stem Cells. (2022)
- PMC: A prospective single-arm study on the effects of repeated intravenous infusions of canine adipose-derived mesenchymal stromal cells in dogs with chronic inflammatory enteropathy. (2025)
- PMC: Isolation of Secretome with Enhanced Antifibrotic Properties from miR-214-Transfected Adipose-Derived Stem Cells. (2019)
- MHLW (Japan): Regenerative Medicine — Ministry of Health, Labour and Welfare, Japan
Supervising Physician
Director, Medical Corporation Shimada Clinic
Head of Clinical Practice, Grand Green Osaka Umekita Clinic
Hidenori Shimada
Graduated from the University of Tokushima Faculty of Medicine in 2005. After his initial residency, he obtained U.S. medical certification (ECFMG) and trained as a sub-intern in general surgery at the University of Washington. After completing the doctoral program at Kyoto University Graduate School of Medicine and working as a researcher at the Center for iPS Cell Research and Application (CiRA), Kyoto University, he founded Shimada Clinic in 2013. At Grand Green Osaka Umekita Clinic (https://umekitaclinic.org), he is engaged in a wide range of care, from internal medicine and pediatrics to cell therapy and aesthetic medicine.
* The physician supervision of this article covers its academic content only and does not constitute a recommendation of any specific treatment or product.