Hello, I am Dr. Hidenori Shimada of Grand Green Osaka Umekita Clinic in Osaka, Japan.
If you are researching regenerative medicine, you may already have read about adipose-derived stem cell therapy and wondered what a first appointment actually involves. Arriving with the right questions makes the consultation more useful, especially if you are traveling from overseas or living in Japan as a foreign resident. This guide explains how to prepare for a conversation about adipose-derived stem cell therapy at Grand Green Osaka Umekita Clinic in Osaka.
The short answer: treat the first visit as a medical discussion, not a purchase decision. A physician needs to review your history, explain what the treatment can and cannot be expected to do, and help you decide whether it is appropriate for you.
What should you understand before the consultation?
Adipose-derived stem cell therapy is a regenerative approach in which mesenchymal stem cells are taken from a very small amount of your own fat tissue, cultured and expanded at a specialized facility, and then returned to your body by intravenous infusion. Because the cells come from you, the treatment is described as autologous.
Mesenchymal stem cells are somatic stem cells found in fat tissue, bone marrow and other sources. Laboratory and clinical studies have reported that they can secrete anti-inflammatory substances and growth factors that may support tissue repair. However, research results vary by condition, cell preparation and study design, and a finding in one study should not be generalized to every patient. Reading a few plain-language overviews from public sources such as PubMed or Japanese government pages can help you form realistic expectations.
It is also worth knowing that this is a self-pay (non-insured) treatment. It is not covered by Japan’s national health insurance, so costs, the number of sessions and the overall timeline are matters to confirm directly with the clinic.
Which questions should you bring to the doctor?
A written list keeps the consultation focused. Many international patients find it helpful to prepare questions in their own language first and then check the key terms with the clinic’s multilingual support. Useful topics include the following.
- Why is this treatment being considered for my situation, and what are the other options, including standard care I am already receiving?
- What are the possible risks and side effects of fat collection, cell culture and intravenous infusion?
- What is the full fee structure, and which items are included or billed separately?
- How many visits are needed, and how long does the process take from collection to infusion?
- What happens if my cells cannot be cultured as planned, or if I decide to stop?
There is no single correct list. The aim is to leave the appointment understanding the purpose, the process and the uncertainties, rather than hoping for a particular outcome.
How does Japan’s regulatory framework affect what you should ask?
In Japan, regenerative medicine that uses cultured cells is provided under the Act on the Safety of Regenerative Medicine. Clinics must submit a treatment plan that is reviewed through the system established by this law, and the cell culture is carried out at facilities designated for that purpose. This framework exists to manage quality and patient protection, but it does not mean that a particular treatment has been proven effective for every condition.
For that reason, it is reasonable to ask the clinic to explain which provision plan covers the treatment you are considering, how your cells are handled, and how adverse events are monitored and reported. Clear, calm answers to these questions are a good sign that the clinic takes the process seriously. If something is unclear, ask again or request written information before deciding.
What practical points matter for overseas and resident foreign patients?
The process involves more than one step: a consultation and screening, a small fat collection under local anesthesia, a waiting period while cells are cultured, and later an infusion visit. Both collection and infusion are performed on an outpatient basis, but the timing across these visits should be planned with care if you are traveling.
Before booking flights or accommodation, ask which parts can be discussed in advance, which tests may be needed, and how follow-up is handled after you return home. Bring your medical records, a current medication list and any imaging or test results in English or Japanese if possible. Tell the doctor about allergies, past surgeries, ongoing treatment and any health concerns, since these affect whether the treatment is suitable.
Grand Green Osaka Umekita Clinic is located in the Umeda area of Osaka, which is convenient to reach from Osaka Station and major transport links. The clinic offers an information page for international patients, and you can use it to check the available languages and how to get in touch before your visit.
How can you decide whether to go ahead?
After the consultation, give yourself time. A good decision is based on the doctor’s assessment, your own priorities and a clear understanding of the costs and risks, not on pressure or on stories you have read online. Individual experiences differ, and no account from another patient can predict your own result.
If you have a medical condition that is being treated elsewhere, do not stop or change your current care without talking to the physician who looks after you. Adipose-derived stem cell therapy should be considered a possible option to discuss with a doctor, not a replacement for standard treatment.
In summary, preparing questions about the purpose, process, fees, risks and Japanese regulation will make your first appointment far more productive. The final judgment about whether the treatment fits your situation rests on a physician’s examination. If you would like to learn more, you can contact Grand Green Osaka Umekita Clinic to ask about the consultation process and what to bring.
- Prepare your questionsPurpose, process and options
- Confirm fees and risksAsk what is billed separately
- Check Japanese regulationAsk about the provision plan
- Plan visits and travelTiming across several visits
This figure is a conceptual diagram that organizes the content of the article
References
- PubMed: Glycocalyx-edited mesenchymal stem/stromal cell therapy in advanced osteoporosis. (2026)
- PubMed: Safety and efficacy of autologous, adipose-derived mesenchymal stem cells in patients with rheumatoid arthritis: a phase I/IIa, open-label, non-randomized pilot trial. (2022)
- PubMed: Intravenous Infusion of Autologous Mesenchymal Stem Cells Expanded in Auto Serum for Chronic Spinal Cord Injury Patients: A Case Series. (2024)
- PubMed: Adipose-derived, autologous mesenchymal stem cell therapy for patients with post-COVID-19 syndrome: an intermediate-size expanded access program. (2023)
- PubMed: Autologous bone marrow-derived mesenchymal stem cells for interstitial fibrosis and tubular atrophy: a pilot study. (2021)
- PMC: Evaluation of Multiple Intravenous Infusions of Autologous Adipose-Derived Mesenchymal Stem Cells in Parkinson's Disease: A Randomized, Double-Blind Clinical Trial. (2026)
- PMC: Functional recovery of a 41-year-old quadriplegic spinal cord injury patient following multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells: a case report. (2023)
- PMC: A prospective single-arm study on the effects of repeated intravenous infusions of canine adipose-derived mesenchymal stromal cells in dogs with chronic inflammatory enteropathy. (2025)
- MHLW (Japan): Regenerative Medicine — Ministry of Health, Labour and Welfare, Japan
Supervising Physician
Director, Medical Corporation Shimada Clinic
Head of Clinical Practice, Grand Green Osaka Umekita Clinic
Hidenori Shimada
Graduated from the University of Tokushima Faculty of Medicine in 2005. After his initial residency, he obtained U.S. medical certification (ECFMG) and trained as a sub-intern in general surgery at the University of Washington. After completing the doctoral program at Kyoto University Graduate School of Medicine and working as a researcher at the Center for iPS Cell Research and Application (CiRA), Kyoto University, he founded Shimada Clinic in 2013. At Grand Green Osaka Umekita Clinic (https://umekitaclinic.org), he is engaged in a wide range of care, from internal medicine and pediatrics to cell therapy and aesthetic medicine.
* The physician supervision of this article covers its academic content only and does not constitute a recommendation of any specific treatment or product.