Hello, I am Dr. Hidenori Shimada of Grand Green Osaka Umekita Clinic in Osaka, Japan.
If you are thinking about adipose-derived stem cell therapy in Japan, the most useful preparation happens before you ever sit down with a doctor. Knowing which parts of your health history to bring, and why they matter, makes the consultation more productive and helps the medical team judge whether the treatment is a reasonable option for you. This guide explains what to prepare for a conversation at Grand Green Osaka Umekita Clinic in Osaka, and why each topic is relevant.
In short, you should be ready to describe your current conditions, past surgeries, medications, allergies and your goals for treatment. Whether this therapy suits you is always a decision made by a physician after an in-person assessment, not something an article or a website can determine.
Why your medical history matters for a regenerative treatment
Adipose-derived stem cell therapy is a regenerative medicine approach in which a small amount of your own fat tissue is collected, mesenchymal stem cells are cultured and expanded at a specialized facility, and the cells are later returned by intravenous infusion. Because the cells come from your own body, the treatment is described as autologous. That does not mean it is suitable for everyone. Each step, from the fat collection under local anesthesia to the infusion, interacts with your general health in some way.
For example, a doctor may want to know whether you have a bleeding tendency, whether you have had reactions to local anesthetics, or whether you have an active infection. These details influence how safely a procedure can be planned. They also help the doctor explain which risks and side effects are relevant to you personally, rather than offering only general information.
Information to gather before the consultation
A little organization goes a long way, especially if you will be explaining your history through an interpreter or in a second language. Consider preparing the following items in advance, in writing if possible.
- A list of current and past diagnoses, including chronic conditions and any history of cancer or autoimmune disease
- Past surgeries and hospital stays, with approximate dates
- All regular medications, supplements and over-the-counter products, with names and doses
- Known allergies, particularly to anesthetics, antibiotics, latex or adhesives
- Recent test results or medical summaries from your home country, translated into English if you have them
- Any other regenerative or cell-based treatments you have already received
If you take blood thinners or have a condition that affects healing, mention it clearly. The doctor decides whether any medication needs to be adjusted, and you should never stop a prescribed medicine on your own because of something you read online.
Be clear about your goals and your questions
Doctors can give more meaningful guidance when they understand what you hope to achieve. Instead of saying only that you want to feel better, try to describe the specific concerns that brought you to the consultation, how long you have had them and what treatments you have already tried. Research on mesenchymal stem cells is advancing worldwide, but evidence varies by condition, and results differ from person to person. A good consultation should leave you with realistic expectations rather than guarantees.
It is also worth writing down your questions. You might ask how the process is staged, how long each step typically takes, what the doctor sees as the main uncertainties, and what alternatives exist, including standard medical care. Treating stem cell therapy as one option to be weighed, not as a replacement for established treatment, is a sound way to approach the decision.
Understand the legal framework, costs and follow-up
In Japan, regenerative medicine is regulated under the Act on the Safety of Regenerative Medicine. Clinics that offer these treatments provide them under a regenerative medicine provision plan that is reviewed under the law. This framework governs how treatment is planned and managed, but it does not guarantee a particular outcome. You can ask the clinic how it handles safety management and what happens if a concern arises after treatment.
Adipose-derived stem cell therapy is a self-pay treatment and is not covered by Japan’s public health insurance. Fees, the number of sessions, the treatment period and the possible risks and side effects should all be confirmed with the doctor before you decide. Compare the written information you receive with the clinic’s fee and flow pages, and ask for clarification on anything that is unclear. If you are traveling to Japan, also ask about follow-up after you return home, since you may not be able to visit the clinic again easily.
Using multilingual information and booking a consultation in Osaka
Grand Green Osaka Umekita Clinic is located in the Umeda area of Osaka, which is convenient to reach by train from many parts of Japan. The clinic provides information pages for international patients, so you can read the basics of the treatment in English before you arrive. Reading these pages first lets you use your consultation time for questions about your own situation.
When you contact the clinic, you can mention your preferred language and ask what support is available during the visit. A short summary of your history and goals, sent ahead of time if the clinic allows it, can make the first appointment smoother.
Key points to remember
Preparing your medical history, medications, allergies and questions helps the doctor assess your situation more carefully. The decision to proceed belongs to you and your physician together, and it should be based on a clear understanding of the legal framework, the self-pay costs, the risks and the limits of current evidence. If you are considering adipose-derived stem cell therapy in Osaka, a consultation is the right place to find out whether it is appropriate for you.
- Medical historyDiagnoses and past surgeries
- Medications and allergiesBring a written list
- Your questionsCosts, risks and alternatives
- Doctor's decisionMade after an in-person visit
This diagram is a conceptual summary of the article content
References
- PubMed: Adipose-derived mesenchymal stem cells for the treatment of Amyotrophic Lateral Sclerosis. A phase I/II safety and efficacy clinical trial. (2025)
- PubMed: Efficacy and safety of autologous adipose-derived stem cells in subjects with moderate to severe atopic dermatitis: a multicenter, randomized, single-blind, placebo-controlled, phase 2 trial. (2025)
- PubMed: Beneficial effects of autologous mesenchymal stem cell transplantation in active progressive multiple sclerosis. (2020)
- PubMed: Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke. (2021)
- PubMed: Safety and efficacy of autologous, adipose-derived mesenchymal stem cells in patients with rheumatoid arthritis: a phase I/IIa, open-label, non-randomized pilot trial. (2022)
- PMC: Corneal Regeneration Using Adipose-Derived Mesenchymal Stem Cells. (2022)
- PMC: Efficacy of Human Adipose Derived Mesenchymal Stem Cells in Promoting Skin Wound Healing. (2022)
- PMC: Safety and feasibility of intravenous fresh adipose-derived mesenchymal stem cells in secondary progressive multiple sclerosis: phase I/IIa clinical results. (2026)
- MHLW (Japan): Regenerative Medicine — Ministry of Health, Labour and Welfare, Japan
Supervising Physician
Director, Medical Corporation Shimada Clinic
Head of Clinical Practice, Grand Green Osaka Umekita Clinic
Hidenori Shimada
Graduated from the University of Tokushima Faculty of Medicine in 2005. After his initial residency, he obtained U.S. medical certification (ECFMG) and trained as a sub-intern in general surgery at the University of Washington. After completing the doctoral program at Kyoto University Graduate School of Medicine and working as a researcher at the Center for iPS Cell Research and Application (CiRA), Kyoto University, he founded Shimada Clinic in 2013. At Grand Green Osaka Umekita Clinic (https://umekitaclinic.org), he is engaged in a wide range of care, from internal medicine and pediatrics to cell therapy and aesthetic medicine.
* The physician supervision of this article covers its academic content only and does not constitute a recommendation of any specific treatment or product.