Hello, I am Dr. Hidenori Shimada of Grand Green Osaka Umekita Clinic in Osaka, Japan.
If you live abroad or are visiting Japan, the idea of adipose-derived stem cell therapy in Osaka can raise practical questions long before it raises medical ones. What should you bring? How will language be handled? What will the doctor actually ask? This article walks through how to prepare for a first consultation at Grand Green Osaka Umekita Clinic, so that your time with the physician is spent on the questions that matter.
In short, a good consultation starts with clear medical records, a realistic understanding of what this treatment is, and a written list of questions. Whether treatment is appropriate for you is a decision that only a physician can make after examining you.
What is adipose-derived stem cell therapy, in plain terms?
Adipose-derived stem cell therapy is a regenerative medicine approach in which a very small amount of your own fat tissue is collected under local anesthesia. Mesenchymal stem cells contained in that tissue are cultured and expanded at a specialized facility, and the cells are later returned to your body by intravenous infusion. Both collection and infusion are carried out on an outpatient basis.
Mesenchymal stem cells have been reported in research to release anti-inflammatory substances and growth factors that may support the repair of damaged tissue. It is important to read this carefully: these are findings from studies, and the research is still developing. Results differ from person to person, and no outcome can be promised in advance.
Understand the framework before you book
In Japan, this therapy is offered as a self-pay (non-insurance) treatment. That means national health insurance does not cover it, and overseas travel insurance is unlikely to cover it either. Clinics providing it must operate under a regenerative medicine provision plan within the framework of Japan’s Act on the Safety of Regenerative Medicine, which sets requirements for how cells are handled and how treatment is explained to patients.
Because fees, the number of sessions, the expected treatment period, possible risks, and side effects depend on your individual condition, they are confirmed with the doctor at consultation. It is reasonable to ask for these details in writing before you decide anything.
What to prepare before your consultation
Doctors can give more meaningful advice when they understand your full medical picture. The following items are commonly helpful to gather in advance:
- A summary of your current diagnoses and the treatments you have already tried, ideally in English or with a translation.
- A list of medications and supplements, including doses, and any known allergies, especially to local anesthetics.
- Recent test results, imaging reports, or discharge summaries from your home country or from other clinics in Japan.
- Information on past surgeries, blood clotting problems, infections, or a history of cancer.
- Your passport or residence card details for registration, and your travel dates if you are visiting from overseas.
If you are currently receiving standard treatment from another physician, bring that information as well. Adipose-derived stem cell therapy is not presented as a replacement for standard medical care, and your existing treatment plan should be discussed openly with the doctor.
Questions worth asking the doctor
A consultation is a two-way conversation. You are not obliged to decide on the day, and a clear list of questions helps you compare information calmly. Consider asking the following:
- Based on my history, is this treatment something you would consider for me, and what are the reasons for or against?
- What are the known risks and possible side effects of fat collection and of infusion, and how are they managed?
- How are the cells cultured and checked for quality before they are returned to me?
- What is the total cost, what does it include, and are there additional charges for follow-up?
- How many visits are required, how long will I need to stay in Osaka, and what happens if I need to postpone?
- What alternatives, including standard treatments, should I weigh alongside this option?
Be cautious about any explanation that sounds absolute. Reliable medical information acknowledges uncertainty, explains limits, and does not rely on personal testimonials as proof.
Language support and practical planning in Osaka
Grand Green Osaka Umekita Clinic is located in the Umeda area of Osaka, which is convenient to reach from Osaka Station and from Kansai International Airport. The clinic provides information pages in multiple languages, including English, to help international patients understand the treatment flow before they visit. These pages are meant to support, not replace, the individual explanation you receive from the doctor.
If you need interpretation during the consultation, mention it when you make your inquiry so that arrangements can be confirmed in advance. Plan some flexibility in your schedule as well, since cell culture and infusion steps involve waiting periods between visits. Confirming the timeline at the consultation helps you avoid booking flights or accommodation too early.
How to think about your decision afterward
After the consultation, take time to review what you heard. Compare the written explanation with your own notes, and consider discussing it with your regular doctor or family. If something remained unclear, contact the clinic again before moving forward. Choosing not to proceed is a fully legitimate outcome of a consultation.
Preparing well will not determine how a treatment works for you, but it will help you ask better questions and understand the answers. To learn more about the treatment flow, fees, and risk information, please review the Adipose-Derived Stem Cell Therapy page on the clinic website and bring any remaining questions to your physician.
- Bring your recordsDiagnoses, medications, test results
- List your questionsRisks, side effects, costs
- Plan your stayInterpretation and schedule
- Doctor decidesBased on your examination
This diagram is a conceptual summary of the article content
References
- PubMed: Topical and intravenous administration of human umbilical cord mesenchymal stem cells in patients with diabetic foot ulcer and peripheral arterial disease: a phase I pilot study with a 3-year follow-up. (2022)
- PubMed: Safety and Efficacy of the Intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Patients With Heart Failure: A Phase 1/2 Randomized Controlled Trial (RIMECARD Trial [Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy]). (2017)
- PubMed: Adipose-derived mesenchymal stem cells for the treatment of Amyotrophic Lateral Sclerosis. A phase I/II safety and efficacy clinical trial. (2025)
- PubMed: Clinical Scale MSC-Derived Extracellular Vesicles Enhance Poststroke Neuroplasticity in Rodents and Non-Human Primates. (2025)
- PubMed: Systematic Intravenous Administration of Autologous Mesenchymal Stem Cells Is Safe. (2024)
- PMC: Evaluation of Multiple Intravenous Infusions of Autologous Adipose-Derived Mesenchymal Stem Cells in Parkinson's Disease: A Randomized, Double-Blind Clinical Trial. (2026)
- PMC: Functional recovery of a 41-year-old quadriplegic spinal cord injury patient following multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells: a case report. (2023)
- PMC: Optimal Intravenous Administration Procedure for Efficient Delivery of Canine Adipose-Derived Mesenchymal Stem Cells. (2022)
- MHLW (Japan): Regenerative Medicine — Ministry of Health, Labour and Welfare, Japan
Supervising Physician
Director, Medical Corporation Shimada Clinic
Head of Clinical Practice, Grand Green Osaka Umekita Clinic
Hidenori Shimada
Graduated from the University of Tokushima Faculty of Medicine in 2005. After his initial residency, he obtained U.S. medical certification (ECFMG) and trained as a sub-intern in general surgery at the University of Washington. After completing the doctoral program at Kyoto University Graduate School of Medicine and working as a researcher at the Center for iPS Cell Research and Application (CiRA), Kyoto University, he founded Shimada Clinic in 2013. At Grand Green Osaka Umekita Clinic (https://umekitaclinic.org), he is engaged in a wide range of care, from internal medicine and pediatrics to cell therapy and aesthetic medicine.
* The physician supervision of this article covers its academic content only and does not constitute a recommendation of any specific treatment or product.