Hello, I am Dr. Hidenori Shimada of Grand Green Osaka Umekita Clinic in Osaka, Japan.
If you are researching regenerative medicine in Japan, one of the first practical questions is whether a treatment is suited to your situation at all. Adipose-derived stem cell therapy is offered by Grand Green Osaka Umekita Clinic in Osaka as a self-pay (non-insured) option, and this article explains how international patients can think about candidacy before booking a consultation. It is general information, not a diagnosis, and it cannot tell you whether the treatment is appropriate for you.
Short answer: candidacy is a medical decision made in consultation
There is no checklist that can confirm in advance that someone will or will not receive this treatment. Whether adipose-derived stem cell therapy is an option depends on your medical history, current health, the reason you are interested, and the doctor’s assessment of risks and expected benefits. Outcomes vary between individuals, and no result can be promised. The most useful way to prepare is to understand the type of treatment, gather your records, and arrive with clear questions.
What the treatment involves, in brief
In this therapy, a very small amount of your own fat tissue is collected under local anesthesia. The mesenchymal stem cells contained in that tissue are cultured and expanded at a specialized facility, and the cells are then returned to your body by intravenous infusion. Because the cells come from you, the approach is described as autologous. Collection and infusion are carried out on an outpatient basis, so hospitalization is not part of the plan described on the clinic’s treatment page.
Mesenchymal stem cells have been reported in the research literature to release anti-inflammatory substances and growth factors that may support tissue repair. These findings come from studies of varying size and design, and they should not be read as proof that a particular condition will improve for a particular person.
Factors a doctor is likely to consider
Every clinic sets its own screening process, and the details are explained during consultation. In general, patients can expect the following kinds of topics to come up:
- Your current symptoms and the goal you hope to pursue, discussed realistically.
- Your past and present medical conditions, including any history of cancer, infection, or immune-related disease.
- Medications and supplements you take, including blood thinners, since a small procedure is involved in fat collection.
- Allergies, especially to local anesthetics or other substances used during care.
- Whether you are pregnant or planning pregnancy, and your general physical condition.
- Whether standard medical care has already been tried or is still appropriate for you.
This list is illustrative, not exhaustive, and it does not mean that any single item will rule you in or out. The final judgment rests with the physician who examines you.
Regenerative therapy is not a replacement for standard care
Adipose-derived stem cell therapy is not covered by Japan’s national health insurance, and it should not be understood as a substitute for established treatment. If you have a diagnosed condition, continue to follow the advice of your current doctors. Many patients find it helpful to bring a summary from their home physician so that the consulting doctor in Osaka can see the full picture. If you are unsure how this option fits alongside your existing care, say so directly during the consultation.
How Japan’s legal framework affects what you can expect
In Japan, regenerative medicine of this kind is provided under the Act on the Safety of Regenerative Medicine, which requires a provision plan and oversight of cell processing. This framework governs how treatment is planned, how cells are handled, and what information must be given to patients. It does not mean that any outcome is assured, and it does not remove the need for individual medical assessment. International patients may wish to ask the clinic how the plan applies to their own treatment and how cell processing is managed.
Questions to bring to your consultation in Osaka
Writing down questions beforehand helps you use consultation time well, especially if you are traveling or communicating in a second language. Consider asking:
- Based on my history, is this treatment an option for me, and what are the reasons for or against?
- What are the possible risks and side effects, and what happens if one occurs after I return home?
- What does the full process involve, from the first visit to cell infusion, and how many visits are needed?
- What is the total cost, which items are included, and are there separate charges for consultation or tests?
- What realistic outcomes can I expect, and how is the uncertainty explained?
- Which of my existing records or test results should I bring or send in advance?
Do not rely on fixed numbers you may see elsewhere online for cost, timing, or results. Ask for current, written information from the clinic and confirm it with your doctor.
Planning as an international patient
Grand Green Osaka Umekita Clinic is located in the Umeda area of Osaka, which is convenient to reach from Kansai International Airport and Shin-Osaka Station. The clinic provides an information page for international patients, which is a sensible first stop for checking language support and how to make contact. Because treatment steps may be spread over more than one visit, ask early about scheduling so you can plan travel, work, and follow-up without pressure.
If you decide to proceed to a consultation, it is reasonable to ask for a clear explanation of the treatment, its risks, and its limits before making any decision. You are free to take time, seek a second opinion, or choose not to proceed.
Key takeaways
Whether adipose-derived stem cell therapy suits you can only be decided by a doctor after a consultation. It is a self-pay treatment provided under Japanese regenerative medicine law, it does not replace standard care, and results differ from person to person. Prepare your medical records, write your questions, and confirm costs, risks, and side effects directly with the clinic. You can learn more through the clinic’s treatment page and its information for international patients before arranging a consultation.
- 1Gather your records
- 2List your questions
- 3Ask about the legal plan
- 4Discuss costs and risks
- 5Doctor decides candidacy
This diagram is a conceptual summary of the article content
References
- PubMed: Predictive Factors of Autologous Bone Marrow-Derived Mesenchymal Stem Cell Therapy's Success in the Treatment of Perianal Fistulas in Patients With Crohn's Disease. (2025)
- PMC: Intrathecal transplantation of autologous adipose-derived mesenchymal stem cells for treating spinal cord injury: A human trial. (2016)
- PMC: Efficacy of Human Adipose Derived Mesenchymal Stem Cells in Promoting Skin Wound Healing. (2022)
- PMC: Adipose-derived mesenchymal stem cells for the treatment of Amyotrophic Lateral Sclerosis. A phase I/II safety and efficacy clinical trial. (2025)
- PMC: A review of adipose-derived mesenchymal stem cells' impacts and challenges: metabolic regulation, tumor modulation, immunomodulation, regenerative medicine and genetic engineering therapies. (2025)
- MHLW (Japan): Regenerative Medicine — Ministry of Health, Labour and Welfare, Japan
Supervising Physician
Director, Medical Corporation Shimada Clinic
Head of Clinical Practice, Grand Green Osaka Umekita Clinic
Hidenori Shimada
Graduated from the University of Tokushima Faculty of Medicine in 2005. After his initial residency, he obtained U.S. medical certification (ECFMG) and trained as a sub-intern in general surgery at the University of Washington. After completing the doctoral program at Kyoto University Graduate School of Medicine and working as a researcher at the Center for iPS Cell Research and Application (CiRA), Kyoto University, he founded Shimada Clinic in 2013. At Grand Green Osaka Umekita Clinic (https://umekitaclinic.org), he is engaged in a wide range of care, from internal medicine and pediatrics to cell therapy and aesthetic medicine.
* The physician supervision of this article covers its academic content only and does not constitute a recommendation of any specific treatment or product.